COG6 and GRAP2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		COG6	GRAP2
Description		component of oligomeric golgi complex 6	GRB2 related adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Transport Complex Trans-Golgi Network Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Protein Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Glycosylation	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways		COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs
Diseases
GWAS		Asthma ( 30929738) Asthma (adult onset) ( 30929738) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Psoriasis ( 25903422 18369459) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		17 interacting genes: ARHGEF5 ATXN7 BCL10 CCDC92 CCHCR1 CNN1 FAM90A1 FANCG GOLGA2 GRAP2 LGALS14 MCM7 NDUFA5 NTAQ1 RAB6B SCNM1 ZBTB16	66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526
Entrez ID		57511	9402
HPRD ID		08445	05156
Ensembl ID		ENSG00000133103	ENSG00000100351
Uniprot IDs		A0A024RDW5 A0A140VJG7 Q9Y2V7	B7Z8E3 O75791 Q6FI14
PDB IDs			5GJH
Enriched GO Terms of Interacting Partners?
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