ARHGEF5 and ATP13A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ARHGEF5	ATP13A1
Description		Rho guanine nucleotide exchange factor 5	ATPase 13A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery	Cell Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Molecular_function ATP Binding Manganese-transporting ATPase Activity ATPase Activity Metal Ion Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis G Protein-coupled Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	Cellular Calcium Ion Homeostasis Biological_process Ion Transmembrane Transport Manganese Ion Transmembrane Transport
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Post bronchodilator FEV1/FVC ratio ( 26634245)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Platelet count ( 27863252) Plateletcrit ( 27863252) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Toenail selenium levels ( 25343990)
Interacting Genes		16 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 CRKL EFHC2 FKBP8 HSPBAP1 NR4A1 PLCG1 SEPHS2 SLU7 TRIM27 TRIM54	2 interacting genes: ARHGEF5 GLP1R
Entrez ID		7984	57130
HPRD ID		02932	12501
Ensembl ID		ENSG00000050327	ENSG00000105726
Uniprot IDs		Q12774	A0A024R7N2 Q9HD20
PDB IDs
Enriched GO Terms of Interacting Partners?
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