LRRK1 and SH2D2A

Number of citations of the paper that reports this interaction (PubMedID 29513927)
4

Data Source:
BioGRID (pull down)

		LRRK1	SH2D2A
Description		leucine rich repeat kinase 1	SH2 domain containing 2A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Signaling Adaptor Activity
	Biological Process	Protein Phosphorylation Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways			VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Central corneal thickness ( 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)	Platelet count ( 27863252) SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SELENOS SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP TM2D3 VGLL4	29 interacting genes: APPL1 ARID5A CRK DAPK1 EGFR ERBB2 ITK KDR LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B
Entrez ID		79705	9047
HPRD ID		14319	05152
Ensembl ID		ENSG00000154237	ENSG00000027869
Uniprot IDs		Q38SD2	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs
Enriched GO Terms of Interacting Partners?
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