FA2H and ERLIN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FA2H	ERLIN1
Description		fatty acid 2-hydroxylase	ER lipid raft associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Iron Ion Binding Heme Binding Fatty Acid Alpha-hydroxylase Activity	Protein Binding Cholesterol Binding Ubiquitin Protein Ligase Binding
	Biological Process	Sebaceous Gland Cell Differentiation Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Cell Proliferation Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Oxidation-reduction Process Establishment Of Skin Barrier	Cholesterol Metabolic Process Ubiquitin-dependent ERAD Pathway SREBP Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Transmembrane Transport
Pathways		Sphingolipid de novo biosynthesis	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis
Drugs
Diseases
GWAS		General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		4 interacting genes: CREB3 ERLIN1 LMNA UBQLN4	4 interacting genes: AGR3 FA2H SEC22A TMEM199
Entrez ID		79152	10613
HPRD ID		16873	08502
Ensembl ID		ENSG00000103089	ENSG00000107566
Uniprot IDs		Q7L5A8	O75477
PDB IDs
Enriched GO Terms of Interacting Partners?
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