ERLIN1 and FA2H

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ERLIN1	FA2H
Description		ER lipid raft associated 1	fatty acid 2-hydroxylase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Cholesterol Binding Ubiquitin Protein Ligase Binding	Iron Ion Binding Heme Binding Fatty Acid Alpha-hydroxylase Activity
	Biological Process	Cholesterol Metabolic Process Ubiquitin-dependent ERAD Pathway SREBP Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Transmembrane Transport	Sebaceous Gland Cell Differentiation Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Cell Proliferation Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Oxidation-reduction Process Establishment Of Skin Barrier
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		4 interacting genes: AGR3 FA2H SEC22A TMEM199	4 interacting genes: CREB3 ERLIN1 LMNA UBQLN4
Entrez ID		10613	79152
HPRD ID		08502	16873
Ensembl ID		ENSG00000107566	ENSG00000103089
Uniprot IDs		O75477	Q7L5A8
PDB IDs
Enriched GO Terms of Interacting Partners?
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