WNT2 and FZD1

Number of citations of the paper that reports this interaction (PubMedID 10557084)
33

Data Source:
HPRD (in vivo, in vitro)

		WNT2	FZD1
Description		Wnt family member 2	frizzled class receptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extrinsic Component Of External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Wnt Signalosome	Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Wnt Signalosome
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Neurogenesis Neuron Differentiation Lung Development Cell Proliferation In Midbrain Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation	Positive Regulation Of Protein Phosphorylation Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Epithelial Cell Differentiation Autocrine Signaling Non-canonical Wnt Signaling Pathway Astrocyte-dopaminergic Neuron Signaling Response To Drug Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Hard Palate Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Presynapse Assembly Negative Regulation Of Oxidative Stress-induced Neuron Death Beta-catenin Destruction Complex Disassembly Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342 21732829) Inflammatory bowel disease ( 28067908) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908) Uterine fibroids ( 31649266)	Blond vs. brown/black hair color ( 30531825) Dental caries ( 23259602) Pulse pressure ( 27841878) Schizophrenia ( 31735061) Systolic blood pressure ( 27841878)
Interacting Genes		8 interacting genes: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A	6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A
Entrez ID		7472	8321
HPRD ID		00999	04558
Ensembl ID		ENSG00000105989	ENSG00000157240
Uniprot IDs		A0A384MDX3 P09544	Q9UP38
PDB IDs
Enriched GO Terms of Interacting Partners?
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