WNT2 and AQP5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		WNT2	AQP5
Description		Wnt family member 2	aquaporin 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extrinsic Component Of External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Wnt Signalosome	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Microvillus Basal Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Extracellular Exosome
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity	Protein Binding Water Channel Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Neurogenesis Neuron Differentiation Lung Development Cell Proliferation In Midbrain Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation	Water Transport Carbon Dioxide Transport Pancreatic Juice Secretion Odontogenesis Saliva Secretion Camera-type Eye Morphogenesis Protein Homotetramerization Transmembrane Transport Cellular Hypotonic Response
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Passive transport by Aquaporins
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342 21732829) Inflammatory bowel disease ( 28067908) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908) Uterine fibroids ( 31649266)	Allergic rhinitis ( 30013184)
Interacting Genes		8 interacting genes: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A	8 interacting genes: CREB3 GLRX HNRNPK KRT31 KRT40 MDFI NOTCH2NLA WNT2
Entrez ID		7472	362
HPRD ID		00999	02706
Ensembl ID		ENSG00000105989	ENSG00000161798
Uniprot IDs		A0A384MDX3 P09544	P55064
PDB IDs			3D9S 5C5X 5DYE
Enriched GO Terms of Interacting Partners?
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