NELFA and NSD2

		NELFA	NSD2
Description		negative elongation factor complex member A	nuclear receptor binding SET domain protein 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Nuclear Body NELF Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Multicellular Organism Development Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases			Multiple myeloma
GWAS			Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		6 interacting genes: APP NELFB NELFCD NSD2 PRR22 SIAH1	15 interacting genes: AGO2 APP AR AURKA ESR1 H3-4 H3C1 H3C14 MDC1 NELFA NOP14 PCNA SH3BP2 SLBP SMURF1
Entrez ID		7469	7468
HPRD ID		12080	04259
Ensembl ID		ENSG00000185049	ENSG00000109685
Uniprot IDs		A0A0C4DFX9 Q9H3P2	O96028
PDB IDs		5L3X 6GML	5LSU 5VC8 6UE6
Enriched GO Terms of Interacting Partners?
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