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NELFA and SIAH1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
381
Data Source:
BioGRID
(two hybrid)
NELFA
SIAH1
Description
negative elongation factor complex member A
siah E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Nuclear Body
NELF Complex
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Molecular Function
Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
Multicellular Organism Development
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Viral Transcription
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
28552196
)
Waist circumference (
28552196
)
Interacting Genes
6 interacting genes:
APP
NELFB
NELFCD
NSD2
PRR22
SIAH1
141 interacting genes:
AASDHPPT
AFF1
AFF4
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LMNA
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
MYD88
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
Entrez ID
7469
6477
HPRD ID
12080
03736
Ensembl ID
ENSG00000185049
ENSG00000196470
Uniprot IDs
A0A0C4DFX9
Q9H3P2
Q8IUQ4
PDB IDs
5L3X
6GML
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
Enriched GO Terms of Interacting Partners
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