NSD2 and NOP14

		NSD2	NOP14
Description		nuclear receptor binding SET domain protein 2	NOP14 nucleolar protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Nucleolus Membrane 90S Preribosome Noc4p-Nop14p Complex Small-subunit Processome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	RNA Binding Enzyme Binding SnoRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Multiple myeloma
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Smoking behaviour (cigarettes smoked per day) ( 30679032)
Interacting Genes		15 interacting genes: AGO2 APP AR AURKA ESR1 H3-4 H3C1 H3C14 MDC1 NELFA NOP14 PCNA SH3BP2 SLBP SMURF1	1 interacting genes: NSD2
Entrez ID		7468	8602
HPRD ID		04259	12827
Ensembl ID		ENSG00000109685	ENSG00000087269
Uniprot IDs		O96028	A8KA74 P78316
PDB IDs		5LSU 5VC8 6UE6
Enriched GO Terms of Interacting Partners?
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