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SIAH1 and PKD1
Number of citations of the paper that reports this interaction (PubMedID
15284290
)
10
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
HPRD
(in vivo, two hybrid)
SIAH1
PKD1
Description
siah E3 ubiquitin protein ligase 1
polycystin 1, transient receptor potential channel interacting
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Golgi Membrane
Polycystin Complex
Cell
Nucleus
Cytoplasm
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cilium
Cell Surface
Integral Component Of Membrane
Basolateral Plasma Membrane
Lateral Plasma Membrane
Golgi-associated Vesicle Membrane
Motile Cilium
Cation Channel Complex
Calcium Channel Complex
Ciliary Membrane
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Calcium Channel Activity
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Carbohydrate Binding
Wnt-activated Receptor Activity
Ion Channel Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Cartilage Condensation
In Utero Embryonic Development
Kidney Development
Liver Development
Embryonic Placenta Development
Protein Export From Nucleus
Cell Cycle Arrest
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cytosolic Calcium Ion Concentration
JAK-STAT Cascade
Heart Development
Anatomical Structure Morphogenesis
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Spinal Cord Development
Neural Tube Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion
Positive Regulation Of Protein Binding
Response To Fluid Shear Stress
Lymph Vessel Morphogenesis
Cytoplasmic Sequestering Of Transcription Factor
Skin Development
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Branching Morphogenesis Of An Epithelial Tube
Genitalia Development
Detection Of Mechanical Stimulus
Cartilage Development
Protein Heterotetramerization
Regulation Of Mitotic Spindle Organization
Lung Epithelium Development
Placenta Blood Vessel Development
Regulation Of Proteasomal Protein Catabolic Process
Calcium Ion Transmembrane Transport
Mesonephric Tubule Development
Mesonephric Duct Development
Metanephric Collecting Duct Development
Metanephric Ascending Thin Limb Development
Metanephric Proximal Tubule Development
Metanephric Distal Tubule Morphogenesis
Cell-cell Signaling By Wnt
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
VxPx cargo-targeting to cilium
VxPx cargo-targeting to cilium
Drugs
Diseases
Polycystic kidney disease
GWAS
Height (
28552196
)
Waist circumference (
28552196
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Heel bone mineral density (
30598549
)
Height (
28552196
)
Major depressive disorder (
29317602
)
Systolic blood pressure (
30578418
)
Interacting Genes
141 interacting genes:
AASDHPPT
AFF1
AFF4
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LMNA
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
MYD88
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
29 interacting genes:
ACTN1
ATF7IP
BCAR1
CDH1
COL1A1
COL2A1
CTNNA1
CTNNB1
DES
FN1
HDAC9
JAK2
JUP
KRT18
KRT8
MARK2
NCF1
NCK2
PIP5K1C
PKD2
PTK2
PTPRG
PXN
RGS7
SIAH1
SRC
TLN1
VCL
VIM
Entrez ID
6477
5310
HPRD ID
03736
03203
Ensembl ID
ENSG00000196470
ENSG00000008710
Uniprot IDs
Q8IUQ4
P98161
PDB IDs
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
1B4R
6A70
Enriched GO Terms of Interacting Partners
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