TYROBP and ZAP70

Number of citations of the paper that reports this interaction (PubMedID 9490415)
179

Data Source:
BioGRID (unspecified method)
HPRD (in vitro)

		TYROBP	ZAP70
Description		transmembrane immune signaling adaptor TYROBP	zeta chain of T cell receptor associated protein kinase 70
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GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction T Cell Receptor Complex Membrane Raft
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Metal Ion Binding	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Apoptotic Cell Clearance Neutrophil Degranulation Negative Regulation Of Interleukin-10 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Response To Axon Injury Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Regulation Of Immune Response Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development	Adaptive Immune Response Protein Phosphorylation Immune Response Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Protein Autophosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules
Drugs			Staurosporine
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS			Bipolar disorder ( 31043756) Cardiac Troponin-T levels ( 31014085) Diastolic blood pressure ( 30224653)
Interacting Genes		13 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	62 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 LRRK2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		7305	7535
HPRD ID		04996	01495
Ensembl ID		ENSG00000011600	ENSG00000115085
Uniprot IDs		O43914 X6RGC9	P43403
PDB IDs		2L34 2L35 4WO1 4WOL	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
Enriched GO Terms of Interacting Partners?
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