TYROBP and SIRPB1

Number of citations of the paper that reports this interaction (PubMedID 10604985)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TYROBP	SIRPB1
Description		transmembrane immune signaling adaptor TYROBP	signal regulatory protein beta 1
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GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Apoptotic Cell Clearance Neutrophil Degranulation Negative Regulation Of Interleukin-10 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Response To Axon Injury Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Regulation Of Immune Response Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development	Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Neutrophil Degranulation Innate Immune Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	DAP12 interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Blood protein levels ( 30072576 29875488) Mean platelet volume ( 27863252) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	4 interacting genes: DAB1 MEOX2 RBPMS TYROBP
Entrez ID		7305	10326
HPRD ID		04996	04866
Ensembl ID		ENSG00000011600	ENSG00000101307
Uniprot IDs		O43914 X6RGC9	H9KV29 O00241 Q5TFQ8
PDB IDs		2L34 2L35 4WO1 4WOL	2D9C 2JJU 2JJV
Enriched GO Terms of Interacting Partners?
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