TYROBP and SIGLEC14

Number of citations of the paper that reports this interaction (PubMedID 17012248)
47

Data Source:
HPRD (in vivo)

		TYROBP	SIGLEC14
Description		transmembrane immune signaling adaptor TYROBP	sialic acid binding Ig like lectin 14
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane	Plasma Membrane Integral Component Of Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Metal Ion Binding	Carbohydrate Binding Sialic Acid Binding
	Biological Process	Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Apoptotic Cell Clearance Neutrophil Degranulation Negative Regulation Of Interleukin-10 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Response To Axon Injury Positive Regulation Of Interleukin-1 Beta Biosynthetic Process Regulation Of Immune Response Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development	Cell Adhesion Neutrophil Degranulation Innate Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	DAP12 interactions Neutrophil degranulation
Drugs
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Blood protein levels ( 30072576 29875488 28240269) Plasma plasminogen levels ( 25208887)
Interacting Genes		13 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	1 interacting genes: TYROBP
Entrez ID		7305	100049587
HPRD ID		04996	19304
Ensembl ID		ENSG00000011600	ENSG00000254415
Uniprot IDs		O43914 X6RGC9	Q08ET2
PDB IDs		2L34 2L35 4WO1 4WOL
Enriched GO Terms of Interacting Partners?
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