TXK and NELFCD

Number of citations of the paper that reports this interaction (PubMedID 14684750)
4

Data Source:
HPRD (in vitro)

		TXK	NELFCD
Description		TXK tyrosine kinase	negative elongation factor complex member C/D
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleoplasm Membrane NELF Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	RNA Binding Protein Binding
	Biological Process	Cytokine Production Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252)	Mean platelet volume ( 27863252) Platelet distribution width ( 27863252)
Interacting Genes		11 interacting genes: CCR5 CLNK CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1	19 interacting genes: AAMP AR ARAF ARPC4 CACNA1A DNAJA1 ENDOV EPRS1 FRMD5 GSTM4 HDAC11 MTA1 NELFA PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638
Entrez ID		7294	51497
HPRD ID		02505	16096
Ensembl ID		ENSG00000074966	ENSG00000101158
Uniprot IDs		P42681	H0UI80 Q8IXH7
PDB IDs		2DM0	5L3X 6GML
Enriched GO Terms of Interacting Partners?
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