TXK and LCP2

Number of citations of the paper that reports this interaction (PubMedID 8702662)
85

Data Source:
HPRD (in vitro, in vivo)

		TXK	LCP2
Description		TXK tyrosine kinase	lymphocyte cytosolic protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Cytokine Production Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity Cytokine Secretion T Cell Receptor Signaling Pathway
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252)	Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		11 interacting genes: CCR5 CLNK CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1	43 interacting genes: APP BLNK CBL CD22 CLNK EGFR FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LARP1 LAT LCK LMNA LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		7294	3937
HPRD ID		02505	03362
Ensembl ID		ENSG00000074966	ENSG00000043462
Uniprot IDs		P42681	Q13094
PDB IDs		2DM0	1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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