TXK and CLNK

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		TXK	CLNK
Description		TXK tyrosine kinase	cytokine dependent hematopoietic cell linker
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Cytoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	SH3/SH2 Adaptor Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Cytokine Production Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Death Negative Regulation Of Natural Killer Cell Activation Intracellular Signal Transduction
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256) Resistance to antihypertensive treatment in hypertension ( 28222112) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Urate levels ( 31578528) Uterine fibroid size (maximum dimension) ( 30196971) Vitiligo ( 22561518)
Interacting Genes		11 interacting genes: CCR5 CLNK CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1	30 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD JAKMIP1 LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX
Entrez ID		7294	116449
HPRD ID		02505	14720
Ensembl ID		ENSG00000074966	ENSG00000109684
Uniprot IDs		P42681	Q7Z7G1
PDB IDs		2DM0
Enriched GO Terms of Interacting Partners?
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