C1QA and GNPNAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		C1QA	GNPNAT1
Description		complement C1q A chain	glucosamine-phosphate N-acetyltransferase 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Synapse Collagen-containing Extracellular Matrix Postsynapse	Golgi Membrane Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endosome Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding	Glucosamine 6-phosphate N-acetyltransferase Activity N-acetyltransferase Activity Identical Protein Binding Monosaccharide Binding
	Biological Process	Microglial Cell Activation Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Aging Response To Iron Ion Viral Process Neuron Remodeling Regulation Of Complement Activation Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death	Liver Development Glucosamine Metabolic Process N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Synthesis of UDP-N-acetyl-glucosamine
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS			Blood protein levels ( 30072576) Prostate cancer ( 23535732) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		28 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 RHOA SGTA SLC25A47 UBQLN1 UBQLN2	2 interacting genes: C1QA NAGK
Entrez ID		712	64841
HPRD ID		00393	17046
Ensembl ID		ENSG00000173372	ENSG00000100522
Uniprot IDs		A0A024RAG6 P02745	A0A024R649 Q96EK6
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ	2HUZ 2O28 3CXP 3CXQ 3CXS
Enriched GO Terms of Interacting Partners?
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