GNPNAT1 and C1QA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GNPNAT1	C1QA
Description		glucosamine-phosphate N-acetyltransferase 1	complement C1q A chain
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GO Annotations	Cellular Component	Golgi Membrane Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endosome Membrane	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Synapse Collagen-containing Extracellular Matrix Postsynapse
	Molecular Function	Glucosamine 6-phosphate N-acetyltransferase Activity N-acetyltransferase Activity Identical Protein Binding Monosaccharide Binding	Amyloid-beta Binding Protein Binding
	Biological Process	Liver Development Glucosamine Metabolic Process N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Microglial Cell Activation Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Aging Response To Iron Ion Viral Process Neuron Remodeling Regulation Of Complement Activation Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		2 interacting genes: C1QA NAGK	28 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 RHOA SGTA SLC25A47 UBQLN1 UBQLN2
Entrez ID		64841	712
HPRD ID		17046	00393
Ensembl ID		ENSG00000100522	ENSG00000173372
Uniprot IDs		A0A024R649 Q96EK6	A0A024RAG6 P02745
PDB IDs		2HUZ 2O28 3CXP 3CXQ 3CXS	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ
Enriched GO Terms of Interacting Partners?
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