TLE4 and OTX1

Number of citations of the paper that reports this interaction (PubMedID 15105370)
65

Data Source:
HPRD (in vivo)

		TLE4	OTX1
Description		TLE family member 4, transcriptional corepressor	orthodenticle homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Beta-catenin-TCF Complex	Nuclear Chromatin
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Molecular_function Chromatin Binding Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Biological_process Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Cellular Response To Leukemia Inhibitory Factor	Anterior/posterior Pattern Specification Metencephalon Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Lymphocyte counts ( 27863252) Motion sickness ( 25628336) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Type 2 diabetes ( 22885922 24509480 30297969 26818947 30718926 28869590)	Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		9 interacting genes: BRCA1 CUX1 LIG4 MSX1 OTX1 OTX2 PAX5 POU2F1 SRPK2	47 interacting genes: ADAMTSL4 CHIC2 CHRD COMP DPY30 FBLN5 GEMIN8P4 GRN KCNK16 KRT81 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE4A MDFI MGAT5B MTNR1B RBPMS RGS17 RGS20 SMARCC1 SPRY1 SPRY2 TLE4 TNS2 VWC2L
Entrez ID		7091	5013
HPRD ID		05502	08964
Ensembl ID		ENSG00000106829	ENSG00000115507
Uniprot IDs		Q04727	P32242
PDB IDs
Enriched GO Terms of Interacting Partners?
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