TLE4

Description		TLE family member 4, transcriptional corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Beta-catenin-TCF Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Molecular_function Chromatin Binding Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Biological_process Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Lymphocyte counts ( 27863252) Motion sickness ( 25628336) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Type 2 diabetes ( 22885922 24509480 30297969 26818947 30718926 28869590)
Interacting Genes		9 interacting genes: BRCA1 CUX1 LIG4 MSX1 OTX1 OTX2 PAX5 POU2F1 SRPK2
Entrez ID		7091
HPRD ID		05502
Ensembl ID		ENSG00000106829
Uniprot IDs		Q04727
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?