TLE1 and GOLM1

		TLE1	GOLM1
Description		TLE family member 1, transcriptional corepressor	golgi membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Beta-catenin-TCF Complex	Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Integral Component Of Plasma Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Repressing Transcription Factor Binding	Protein Binding
	Biological Process	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Anoikis	Nucleus Organization Regulation Of Lipid Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Blood protein levels ( 30072576) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		88 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 DNAH5 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GKAP1 GOLM1 GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 KIF27 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64	27 interacting genes: B3GNT4 C1orf174 CIAO1 CLK1 DCK DCTN2 DEXI EFTUD2 EIF2B3 EIF3J ELAC2 FLOT1 FTH1 GEMIN7 GRIK5 KCNE3 LSM12 MED22 NIPSNAP3A NRSN2 RACK1 RPA2 RPL13A SLC40A1 SYT1 TLE1 ZFAND3
Entrez ID		7088	51280
HPRD ID		02557	08428
Ensembl ID		ENSG00000196781	ENSG00000135052
Uniprot IDs		B4DEF9 Q04724 Q59EF7	B3KNK9 Q8NBJ4
PDB IDs		1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?
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