THRSP and PIK3CA

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		THRSP	PIK3CA
Description		thyroid hormone responsive	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cell Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane Lamellipodium
	Molecular Function	Identical Protein Binding Protein Homodimerization Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	Lipid Metabolic Process Carnitine Shuttle Response To Bacterium Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Biosynthetic Process	Angiogenesis Liver Development Vasculature Development Glucose Metabolic Process Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axon Guidance Regulation Of Gene Expression Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Macroautophagy Phosphorylation Cell Migration Cytokine-mediated Signaling Pathway Platelet Activation T Cell Costimulation Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway Regulation Of Multicellular Organism Growth Anoikis Regulation Of Cellular Respiration Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Hypomethylation Of CpG Island Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Contraction Adipose Tissue Development Cellular Response To Glucose Stimulus Energy Homeostasis Negative Regulation Of Fibroblast Apoptotic Process Regulation Of Genetic Imprinting Negative Regulation Of Anoikis
Pathways		Carnitine metabolism	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Extra-nuclear estrogen signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Activated NTRK3 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants
Drugs			ATP Caffeine XL765 (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE Pilaralisib Copanlisib
Diseases			Ovarian cancer
GWAS		Menarche (age at onset) ( 25231870) Tourette syndrome ( 30818990)	Mean corpuscular hemoglobin ( 29403010)
Interacting Genes		22 interacting genes: AKT1 AURKA BAG4 BCAR3 BRMS1 ERBB2 FGFR4 FZR1 HMMR IGF1R KRAS LSP1 PALB2 PARP1 PIK3CA PTPN1 RB1CC1 SMAD4 STK11 TGFB1 TSG101 WT1	64 interacting genes: ADAP1 AKT1 AMBP APLP2 APPL1 ARAF ATP5IF1 ATR BEX1 BEX2 CCND2 CSF1R CYTH2 CYTH3 DDX5 DNAJB6 EGFR FASLG FTL GABRB1 GLIS2 GNAQ GRIN2B HRAS IL13RA2 IL24 IL3 IRS2 IRS4 ITIH1 KRAS LCK MRAS MYC NEDD4L NEDD9 NRAS PDGFRA PDGFRB PDK1 PIK3R1 PIK3R3 PRKCD PSMC3IP PTPN11 RASD2 RASGRP3 RELA RPS20 RPS6KB1 SGK1 SH3KBP1 SMAD2 SMAD3 SNX9 SQSTM1 STAT1 STK11 THRSP TICAM1 TNFSF13 UFD1 UMPS VARS2
Entrez ID		7069	5290
HPRD ID		03566	01382
Ensembl ID		ENSG00000151365	ENSG00000121879
Uniprot IDs		Q92748	P42336 Q4LE51
PDB IDs			2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1 5XGH 5XGI 5XGJ 6GVF 6GVG 6GVH 6GVI 6NCT 6OAC 6PYS
Enriched GO Terms of Interacting Partners?
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