KNG1 and AGT

Number of citations of the paper that reports this interaction (PubMedID 11677365)
13

Data Source:
HPRD (in vivo)

		KNG1	AGT
Description		kininogen 1	angiotensinogen
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Endoplasmic Reticulum Lumen Plasma Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cell Cytosol Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding
	Biological Process	Platelet Degranulation Inflammatory Response Negative Regulation Of Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Vasodilation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Proteolysis	Activation Of MAPK Activity Regulation Of Cell Growth Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Regulation Of Heart Rate Regulation Of Blood Vessel Diameter By Renin-angiotensin Renal System Process Angiotensin-mediated Drinking Behavior Positive Regulation Of Extracellular Matrix Constituent Secretion Protein Import Into Nucleus Cellular Sodium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Cell-cell Signaling Female Pregnancy Aging Regulation Of Blood Pressure Associative Learning Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Regulation Of Norepinephrine Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Angiogenesis Regulation Of Lipid Metabolic Process Regulation Of Vasoconstriction Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Tissue Remodeling Low-density Lipoprotein Particle Remodeling Operant Conditioning Regulation Of Renal Sodium Excretion Positive Regulation Of Renal Sodium Excretion Regulation Of Cell Proliferation Vasodilation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Smooth Muscle Cell Proliferation Cytokine Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Calcium Ion Transport Regulation Of Transmission Of Nerve Impulse Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Tyrosine Kinase Activity ERK1 And ERK2 Cascade Uterine Smooth Muscle Contraction Cellular Response To Mechanical Stimulus Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Extracellular Matrix Assembly Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Cellular Response To Angiotensin Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of L-lysine Import Across Plasma Membrane Positive Regulation Of L-arginine Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Zinc Copper	Zinc Copper Sparsentan
Diseases			Renal tubular dysgenesis
GWAS		Activated partial thromboplastin time ( 22703881 29403010 20303064) Adiponectin levels ( 20876611) Blood metabolite levels ( 24816252) Blood protein levels ( 30072576 29875488 28240269) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pancreatic ductal adenocarcinoma ( 30541042) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		28 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	22 interacting genes: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB ITSN2 KNG1 MAS1 MEP1A MME PRCP PREP PRG2 REN TP53
Entrez ID		3827	183
HPRD ID		01970	00106
Ensembl ID		ENSG00000113889	ENSG00000135744
Uniprot IDs		P01042	B0ZBE2 B2R5S1 P01019
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y	1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS 5E2Q 5M3X 5M3Y 5XJM 6I3F 6I3I
Enriched GO Terms of Interacting Partners?
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