TDGF1 and FARSA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TDGF1	FARSA
Description		teratocarcinoma-derived growth factor 1	phenylalanyl-tRNA synthetase subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	TRNA Binding RNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation Protein Heterotetramerization
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Cytosolic tRNA aminoacylation
Drugs			L-Phenylalanine
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Metabolite levels ( 23823483)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	9 interacting genes: A2M ABI3 APOE ECSIT ESR1 GORAB HNRNPR RNF32 TDGF1
Entrez ID		6997	2193
HPRD ID		01757	04227
Ensembl ID		ENSG00000241186	ENSG00000179115
Uniprot IDs		F5H1T8 P13385	Q6IBR2 Q9Y285
PDB IDs			3L4G
Enriched GO Terms of Interacting Partners?
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