FARSA and TDGF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FARSA	TDGF1
Description		phenylalanyl-tRNA synthetase subunit alpha	teratocarcinoma-derived growth factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft
	Molecular Function	TRNA Binding RNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation Protein Heterotetramerization	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Cytosolic tRNA aminoacylation	Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs		L-Phenylalanine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)	Blood protein levels ( 30072576 29875488 28240269) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: A2M ABI3 APOE ECSIT ESR1 GORAB HNRNPR RNF32 TDGF1	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		2193	6997
HPRD ID		04227	01757
Ensembl ID		ENSG00000179115	ENSG00000241186
Uniprot IDs		Q6IBR2 Q9Y285	F5H1T8 P13385
PDB IDs		3L4G
Enriched GO Terms of Interacting Partners?
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