TDGF1 and ACVR1C

Number of citations of the paper that reports this interaction (PubMedID 11485994)
80

Data Source:
HPRD (in vivo)

		TDGF1	ACVR1C
Description		teratocarcinoma-derived growth factor 1	activin A receptor type 1C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft	Plasma Membrane Receptor Complex Activin Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	Protein Serine/threonine Kinase Activity ATP Binding Activin Receptor Activity, Type I Growth Factor Binding Nodal Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Trophectodermal Cell Proliferation Response To Dietary Excess Protein Phosphorylation Nervous System Development Response To Glucose Lipid Storage Cell Differentiation Apoptotic Nuclear Changes Response To Insulin Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Insulin Secretion Cellular Response To Growth Factor Stimulus Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Metabolite levels ( 23823483)	Birth weight ( 31043758) Diastolic blood pressure ( 30224653) Offspring birth weight ( 31043758) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	2 interacting genes: INHBB TDGF1
Entrez ID		6997	130399
HPRD ID		01757	10608
Ensembl ID		ENSG00000241186	ENSG00000123612
Uniprot IDs		F5H1T8 P13385	Q8NER5
PDB IDs
Enriched GO Terms of Interacting Partners?
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