SPTBN2 and SPTA1

Number of citations of the paper that reports this interaction (PubMedID 10852813)
89

Data Source:
HPRD (in vivo)

		SPTBN2	SPTA1
Description		spectrin beta, non-erythrocytic 2	spectrin alpha, erythrocytic 1
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol Spectrin Apical Plasma Membrane Cell Junction Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Structural Constituent Of Synapse	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding
	Biological Process	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping Postsynapse Organization	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process ER To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping
Pathways		MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Bipolar disorder ( 28115744 21926972 31043756)	Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Lymphocyte counts ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neutrophil percentage of white cells ( 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) QRS duration ( 27577874) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		10 interacting genes: ACTA1 ACTB ACTR1A APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B	15 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 VASP YWHAQ
Entrez ID		6712	6708
HPRD ID		05404	01685
Ensembl ID		ENSG00000173898	ENSG00000163554
Uniprot IDs		O15020	P02549
PDB IDs		1WJM 1WYQ 6ANU	1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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