SPTBN2 and UNC13B

Number of citations of the paper that reports this interaction (PubMedID 9704016)
18

Data Source:
HPRD (two hybrid)

		SPTBN2	UNC13B
Description		spectrin beta, non-erythrocytic 2	unc-13 homolog B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Spectrin Apical Plasma Membrane Cell Junction Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton	Cell Golgi Apparatus Cytosol Plasma Membrane Membrane Cell Junction Synaptic Vesicle Membrane Neuromuscular Junction Early Phagosome Presynaptic Membrane Terminal Bouton Calyx Of Held Presynaptic Active Zone Ribbon Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Structural Constituent Of Synapse	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Rab GTPase Binding Diacylglycerol Binding GTP-dependent Protein Binding
	Biological Process	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping Postsynapse Organization	Chemical Synaptic Transmission Neurotransmitter Secretion Neuromuscular Junction Development Positive Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Maturation Negative Regulation Of Synaptic Plasticity Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Short-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Secretion Innervation Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Phagosome Maturation Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Defense Response To Bacterium
Pathways		MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 28115744 21926972 31043756)	Parkinson's disease ( 21812969)
Interacting Genes		10 interacting genes: ACTA1 ACTB ACTR1A APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B	10 interacting genes: CLK1 DOC2A DOC2B RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		6712	10497
HPRD ID		05404	05785
Ensembl ID		ENSG00000173898	ENSG00000198722
Uniprot IDs		O15020	O14795 Q4LE73
PDB IDs		1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?
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