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SMARCD3 and NR1H4
Number of citations of the paper that reports this interaction (PubMedID
14701856
)
62
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
SMARCD3
NR1H4
Description
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
nuclear receptor subfamily 1 group H member 4
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
SWI/SNF Complex
NpBAF Complex
NBAF Complex
Nuclear Chromatin
Cell
Nucleus
Nucleoplasm
Nuclear Euchromatin
Receptor Complex
RNA Polymerase II Transcription Factor Complex
Molecular Function
Chromatin Binding
Transcription Coactivator Activity
Signaling Receptor Binding
Transcription Factor Binding
Nuclear Hormone Receptor Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Nuclear Receptor Binding
Nuclear Receptor Transcription Coactivator Activity
Bile Acid Binding
Signaling Receptor Activity
Bile Acid Receptor Activity
Sequence-specific DNA Binding
Retinoid X Receptor Binding
Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
Chenodeoxycholic Acid Binding
Biological Process
Positive Regulation Of Neuroblast Proliferation
Secondary Heart Field Specification
Cardiac Right Ventricle Formation
Neural Retina Development
Nucleosome Disassembly
Chromatin Remodeling
Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Lipid Metabolic Process
Muscle Cell Differentiation
Regulation Of Protein Binding
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Smooth Muscle Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Nitrogen Catabolite Activation Of Transcription From RNA Polymerase II Promoter
Cellular Glucose Homeostasis
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Lipid Metabolic Process
Inflammatory Response
Cell-cell Junction Assembly
Notch Signaling Pathway
Multicellular Organism Development
Bile Acid Metabolic Process
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Low-density Lipoprotein Particle Clearance
Bile Acid And Bile Salt Transport
Cell Differentiation
Intracellular Receptor Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-1 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Interleukin-6 Production
Response To Lipid
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of Urea Metabolic Process
Histone H3-R17 Methylation
Cellular Triglyceride Homeostasis
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Bile Acid Signaling Pathway
Intracellular Bile Acid Receptor Signaling Pathway
Cholesterol Homeostasis
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Steroid Hormone Mediated Signaling Pathway
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Lipid Homeostasis
Fatty Acid Homeostasis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Bile Acid Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Fatty Acid
Cellular Response To Organonitrogen Compound
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Interleukin-17 Secretion
Regulation Of Cholesterol Metabolic Process
Negative Regulation Of Interferon-gamma Secretion
Cellular Response To Bile Acid
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of Tumor Necrosis Factor Secretion
Positive Regulation Of Phosphatidic Acid Biosynthetic Process
Positive Regulation Of Glutamate Metabolic Process
Positive Regulation Of Ammonia Assimilation Cycle
Pathways
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by PPARalpha
Circadian Clock
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
Endogenous sterols
Drugs
Alpha-Linolenic Acid
Ursodeoxycholic acid
Farnesol
Fexaramine
Cholic Acid
Deoxycholic Acid
Taurocholic Acid
Arachidonic Acid
Obeticholic acid
Chenodeoxycholic acid
(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid
Myrrh
Diseases
GWAS
Eyebrow thickness (
26926045
)
Heel bone mineral density (
30598549
)
IgG glycosylation (
23382691
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Multiple myeloma (
27363682
)
Low density lipoprotein cholesterol levels (
29403010
)
Squamous cell carcinoma (
23341777
)
Interacting Genes
20 interacting genes:
ARHGAP1
CCNE1
ESR1
ESRRA
FANCA
JUN
MAPK14
NR1H4
NR5A1
NR5A2
PBX1
PPARG
RARA
RARB
RARG
RORA
RXRA
SMARCC1
SREBF1
STARD13
15 interacting genes:
CASP8
EP300
ESR1
GAPDH
H3C1
NCOA1
NCOA6
NCOR2
PPARGC1A
RXRA
RXRB
RXRG
SIRT1
SMARCD1
SMARCD3
Entrez ID
6604
9971
HPRD ID
03440
04827
Ensembl ID
ENSG00000082014
ENSG00000012504
Uniprot IDs
A0A090N8Z9
Q6STE5
B6ZGS9
F1DAL1
Q96RI1
PDB IDs
1OSH
1OSK
3BEJ
3DCT
3DCU
3FLI
3FXV
3GD2
3HC5
3HC6
3L1B
3OKH
3OKI
3OLF
3OMK
3OMM
3OOF
3OOK
3P88
3P89
3RUT
3RUU
3RVF
4OIV
4QE6
4QE8
4WVD
5IAW
5ICK
5Q0I
5Q0J
5Q0K
5Q0L
5Q0M
5Q0N
5Q0O
5Q0P
5Q0Q
5Q0R
5Q0S
5Q0T
5Q0U
5Q0V
5Q0W
5Q0X
5Q0Y
5Q0Z
5Q10
5Q11
5Q12
5Q13
5Q14
5Q15
5Q16
5Q17
5Q18
5Q19
5Q1A
5Q1B
5Q1C
5Q1D
5Q1E
5Q1F
5Q1G
5Q1H
5Q1I
5WZX
5Y1J
5Y44
5Y49
5YXB
5YXD
5YXJ
5YXL
5Z12
6A5W
6A5X
6A5Y
6A5Z
6A60
6HL0
6HL1
6ITM
Enriched GO Terms of Interacting Partners
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