NR1H4 and NCOR2

Number of citations of the paper that reports this interaction (PubMedID 16219912)
24

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NR1H4	NCOR2
Description		nuclear receptor subfamily 1 group H member 4	nuclear receptor corepressor 2
Image
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Nuclear Euchromatin Receptor Complex RNA Polymerase II Transcription Factor Complex	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcriptional Repressor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Binding Nuclear Receptor Transcription Coactivator Activity Bile Acid Binding Signaling Receptor Activity Bile Acid Receptor Activity Sequence-specific DNA Binding Retinoid X Receptor Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding Chenodeoxycholic Acid Binding	RNA Polymerase II Regulatory Region DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nitrogen Catabolite Activation Of Transcription From RNA Polymerase II Promoter Cellular Glucose Homeostasis Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Inflammatory Response Cell-cell Junction Assembly Notch Signaling Pathway Multicellular Organism Development Bile Acid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Low-density Lipoprotein Particle Clearance Bile Acid And Bile Salt Transport Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Response To Lipid Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Urea Metabolic Process Histone H3-R17 Methylation Cellular Triglyceride Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Bile Acid Signaling Pathway Intracellular Bile Acid Receptor Signaling Pathway Cholesterol Homeostasis Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Lipid Homeostasis Fatty Acid Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Fatty Acid Cellular Response To Organonitrogen Compound Negative Regulation Of Monocyte Chemotactic Protein-1 Production Interleukin-17 Secretion Regulation Of Cholesterol Metabolic Process Negative Regulation Of Interferon-gamma Secretion Cellular Response To Bile Acid Positive Regulation Of Adipose Tissue Development Negative Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Phosphatidic Acid Biosynthetic Process Positive Regulation Of Glutamate Metabolic Process Positive Regulation Of Ammonia Assimilation Cycle	Negative Regulation Of Transcription By RNA Polymerase II Lactation Response To Organonitrogen Compound Regulation Of Cellular Ketone Metabolic Process Regulation Of Lipid Metabolic Process Response To Estradiol Estrous Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs		Alpha-Linolenic Acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic Acid Taurocholic Acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 29403010) Squamous cell carcinoma ( 23341777)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) Height ( 31562340) Lung function (FEV1) ( 30061609) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: CASP8 EP300 ESR1 GAPDH H3C1 NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRB RXRG SIRT1 SMARCD1 SMARCD3	88 interacting genes: AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CDK2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16 ZBTB7A
Entrez ID		9971	9612
HPRD ID		04827	02910
Ensembl ID		ENSG00000012504	ENSG00000196498
Uniprot IDs		B6ZGS9 F1DAL1 Q96RI1	C9J0Q5 C9JE98 Q9Y618
PDB IDs		1OSH 1OSK 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4OIV 4QE6 4QE8 4WVD 5IAW 5ICK 5Q0I 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q17 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5WZX 5Y1J 5Y44 5Y49 5YXB 5YXD 5YXJ 5YXL 5Z12 6A5W 6A5X 6A5Y 6A5Z 6A60 6HL0 6HL1 6ITM	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?