SLC4A1 and ANK1

Number of citations of the paper that reports this interaction (PubMedID 6449514)
41

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SLC4A1	ANK1
Description		solute carrier family 4 member 1 (Diego blood group)	ankyrin 1
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Exosome Blood Microparticle	Nucleus Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band Sarcolemma Axon Initial Segment Postsynaptic Membrane
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Hemoglobin Binding Ankyrin Binding Protein Homodimerization Activity Protein Membrane Anchor	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Ion Channel Binding ATPase Binding
	Biological Process	Anion Transport Chloride Transport Cellular Ion Homeostasis Blood Coagulation Bicarbonate Transport Phospholipid Scrambling Negative Regulation Of Urine Volume PH Elevation Erythrocyte Development Negative Regulation Of Oxidoreductase Activity Regulation Of Intracellular PH Protein Localization To Plasma Membrane Chloride Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate	Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Bicarbonate transporters Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH) Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP) Distal renal tubular acidosis (RTA type 1)	Hereditary spherocytosis (SPH)
GWAS		Bipolar disorder ( 31043756) Hemoglobin concentration ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Obesity-related traits ( 23251661) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Urate levels ( 31578528)	Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 24647736 20858683 31213470 28898252) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Insulin levels adjusted for BMI ( 24699409) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252 28017375) Mean corpuscular volume ( 27863252) Neutrophil percentage of white cells ( 27863252) Pulmonary function decline ( 22424883) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 30718926 28869590 22456796)
Interacting Genes		13 interacting genes: ACTC1 ANK1 BLOC1S6 CA2 CA4 CANX CDKN2A EPB41 EPB42 LYN RHAG SLC4A1AP SYK	19 interacting genes: BLOC1S6 CD44 EPB42 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC OBSCN RHAG RYR1 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN
Entrez ID		6521	286
HPRD ID		00175	01693
Ensembl ID		ENSG00000004939	ENSG00000029534
Uniprot IDs		P02730	B3KX39 P16157
PDB IDs		1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB 4KY9 4YZF	1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?