SLC4A1 and EPB41

Number of citations of the paper that reports this interaction (PubMedID 1639060)
29

Data Source:
HPRD (in vitro)

		SLC4A1	EPB41
Description		solute carrier family 4 member 1 (Diego blood group)	erythrocyte membrane protein band 4.1
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GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Exosome Blood Microparticle	Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle Cell Cortex Region
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Hemoglobin Binding Ankyrin Binding Protein Homodimerization Activity Protein Membrane Anchor	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Protein C-terminus Binding Spectrin Binding Protein N-terminus Binding Phosphoprotein Binding
	Biological Process	Anion Transport Chloride Transport Cellular Ion Homeostasis Blood Coagulation Bicarbonate Transport Phospholipid Scrambling Negative Regulation Of Urine Volume PH Elevation Erythrocyte Development Negative Regulation Of Oxidoreductase Activity Regulation Of Intracellular PH Protein Localization To Plasma Membrane Chloride Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate	Cell Cycle Regulation Of Cell Shape Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Protein Binding Cell Division Regulation Of Calcium Ion Transport Protein-containing Complex Assembly Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Bicarbonate transporters Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	Neurexins and neuroligins
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH) Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP) Distal renal tubular acidosis (RTA type 1)	Hereditary elliptocytosis (HE)
GWAS		Bipolar disorder ( 31043756) Hemoglobin concentration ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Obesity-related traits ( 23251661) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Urate levels ( 31578528)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Tourette syndrome ( 30818990)
Interacting Genes		13 interacting genes: ACTC1 ANK1 BLOC1S6 CA2 CA4 CANX CDKN2A EPB41 EPB42 LYN RHAG SLC4A1AP SYK	39 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10
Entrez ID		6521	2035
HPRD ID		00175	00558
Ensembl ID		ENSG00000004939	ENSG00000159023
Uniprot IDs		P02730	A0A2R8Y5G2 A0A2R8Y5Z6 A0A2R8Y6D0 A0A2R8Y7Y3 A0A2U3TZH6 P11171 Q1WWM3 Q29RX4 Q59F12
PDB IDs		1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB 4KY9 4YZF	1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?
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