SLC4A1

Description		solute carrier family 4 member 1 (Diego blood group)
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GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Exosome Blood Microparticle
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Hemoglobin Binding Ankyrin Binding Protein Homodimerization Activity Protein Membrane Anchor
	Biological Process	Anion Transport Chloride Transport Cellular Ion Homeostasis Blood Coagulation Bicarbonate Transport Phospholipid Scrambling Negative Regulation Of Urine Volume PH Elevation Erythrocyte Development Negative Regulation Of Oxidoreductase Activity Regulation Of Intracellular PH Protein Localization To Plasma Membrane Chloride Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Bicarbonate transporters Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
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Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH) Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP) Distal renal tubular acidosis (RTA type 1)
GWAS		Bipolar disorder ( 31043756) Hemoglobin concentration ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Obesity-related traits ( 23251661) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Urate levels ( 31578528)
Interacting Genes		13 interacting genes: ACTC1 ANK1 BLOC1S6 CA2 CA4 CANX CDKN2A EPB41 EPB42 LYN RHAG SLC4A1AP SYK
Entrez ID		6521
HPRD ID		00175
Ensembl ID		ENSG00000004939
Uniprot IDs		P02730
PDB IDs		1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB 4KY9 4YZF
Enriched GO Terms of Interacting Partners?
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