SLC1A1 and ARL6IP5

Number of citations of the paper that reports this interaction (PubMedID 11242046)
45

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SLC1A1	ARL6IP5
Description		solute carrier family 1 member 1	ADP ribosylation factor like GTPase 6 interacting protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Early Endosome Membrane Late Endosome Membrane Neuron Projection Synapse Recycling Endosome Membrane Extracellular Exosome	Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Ion Transport Chemical Synaptic Transmission Positive Regulation Of Heart Rate Glutamate Secretion L-glutamate Transmembrane Transport Cysteine Transport L-glutamate Import D-aspartate Import Across Plasma Membrane L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Chloride Transmembrane Transport Cysteine Transmembrane Transport	Negative Regulation Of L-glutamate Import Across Plasma Membrane Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	Glutamate Neurotransmitter Release Cycle
Drugs		L-Aspartic Acid Glutamic Acid
Diseases		Dicarboxylic aminoaciduria
GWAS		Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)	Urate levels ( 31578528)
Interacting Genes		7 interacting genes: APP ARL6IP5 EWSR1 LDLRAD1 LMNA PRKCA RNF5	8 interacting genes: ARL6 CCR5 CLN8 KRAS NOTCH1 PRAF2 SLC1A1 VKORC1
Entrez ID		6505	10550
HPRD ID		00597	09303
Ensembl ID		ENSG00000106688	ENSG00000144746
Uniprot IDs		P43005	A0A024R371 O75915
PDB IDs
Enriched GO Terms of Interacting Partners?
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