SLC1A1 and RNF5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SLC1A1	RNF5
Description		solute carrier family 1 member 1	ring finger protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Early Endosome Membrane Late Endosome Membrane Neuron Projection Synapse Recycling Endosome Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ion Transport Chemical Synaptic Transmission Positive Regulation Of Heart Rate Glutamate Secretion L-glutamate Transmembrane Transport Cysteine Transport L-glutamate Import D-aspartate Import Across Plasma Membrane L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Chloride Transmembrane Transport Cysteine Transmembrane Transport	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Ubiquitin-dependent ERAD Pathway Protein Destabilization ERAD Pathway Cellular Protein Catabolic Process Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination ER-associated Misfolded Protein Catabolic Process Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs		L-Aspartic Acid Glutamic Acid
Diseases		Dicarboxylic aminoaciduria
GWAS		Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)	Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) Waist circumference ( 31453325) Waist circumference variance ( 31453325)
Interacting Genes		7 interacting genes: APP ARL6IP5 EWSR1 LDLRAD1 LMNA PRKCA RNF5	34 interacting genes: ABHD16A CFTR CYB561 CYB561A3 FHOD1 GLP1R INSIG2 JKAMP MAVS MPDZ PXN RNF185 SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z YIPF2
Entrez ID		6505	6048
HPRD ID		00597	04057
Ensembl ID		ENSG00000106688	ENSG00000204308
Uniprot IDs		P43005	A0A024RCQ4 Q99942
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?