ARL6IP5 and SLC1A1

Number of citations of the paper that reports this interaction (PubMedID 11242046)
45

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ARL6IP5	SLC1A1
Description		ADP ribosylation factor like GTPase 6 interacting protein 5	solute carrier family 1 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Early Endosome Membrane Late Endosome Membrane Neuron Projection Synapse Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of L-glutamate Import Across Plasma Membrane Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Ion Transport Chemical Synaptic Transmission Positive Regulation Of Heart Rate Glutamate Secretion L-glutamate Transmembrane Transport Cysteine Transport L-glutamate Import D-aspartate Import Across Plasma Membrane L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Chloride Transmembrane Transport Cysteine Transmembrane Transport
Pathways		Glutamate Neurotransmitter Release Cycle	Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Drugs			L-Aspartic Acid Glutamic Acid
Diseases			Dicarboxylic aminoaciduria
GWAS		Urate levels ( 31578528)	Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		8 interacting genes: ARL6 CCR5 CLN8 KRAS NOTCH1 PRAF2 SLC1A1 VKORC1	7 interacting genes: APP ARL6IP5 EWSR1 LDLRAD1 LMNA PRKCA RNF5
Entrez ID		10550	6505
HPRD ID		09303	00597
Ensembl ID		ENSG00000144746	ENSG00000106688
Uniprot IDs		A0A024R371 O75915	P43005
PDB IDs
Enriched GO Terms of Interacting Partners?
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