LMO2 and ALDH6A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LMO2	ALDH6A1
Description		LIM domain only 2	aldehyde dehydrogenase 6 family member A1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding BHLH Transcription Factor Binding Metal Ion Binding Cofactor Binding E-box Binding	Fatty-acyl-CoA Binding RNA Binding Methylmalonate-semialdehyde Dehydrogenase (acylating) Activity Malonate-semialdehyde Dehydrogenase (acetylating) Activity
	Biological Process	Multicellular Organism Development MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus Regulation Of Hematopoietic Stem Cell Differentiation	Thymine Catabolic Process Valine Metabolic Process Valine Catabolic Process Branched-chain Amino Acid Catabolic Process Thymine Metabolic Process Brown Fat Cell Differentiation Oxidation-reduction Process
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs	Branched-chain amino acid catabolism
Drugs			NADH
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Cognitive performance ( 19734545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)	Blood protein levels ( 28240269) Red cell distribution width ( 27863252)
Interacting Genes		97 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 ALDH6A1 AXIN1 BANP BEX2 BLZF1 C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DRAP1 EHMT2 ELF2 ERBIN FHL3 GATA1 GATA2 GATA3 GFAP GOLGA2 GRB2 HNRNPC HNRNPM HOOK1 IFT43 IHO1 IKZF3 ISL1 KANK2 KDM5A KIF3B KRT15 KRT40 KRTAP10-7 LDB1 LYL1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MRFAP1L1 MTUS2 N4BP2L2 NCAPH2 NHLH1 NIF3L1 NOTCH2NLA NUP62 NUTM1 PDE9A PHC2 PRKG1 RBBP8 REL RELA RINT1 RLIM ROCK1 SAXO1 SKP1 SMAD2 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TFPT TLE5 TLX3 TRIM23 TRIM54 TRIP6 TSC22D4 TUFT1 UBA6 UBE2I ZFP64 ZNF24	1 interacting genes: LMO2
Entrez ID		4005	4329
HPRD ID		01586	04416
Ensembl ID		ENSG00000135363	ENSG00000119711
Uniprot IDs		P25791	A0A024R6G4 Q02252
PDB IDs		2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?
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