CRTC3 and AEN

		CRTC3	AEN
Description		CREB regulated transcription coactivator 3	apoptosis enhancing nuclease
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Nucleic Acid Binding Exonuclease Activity Protein Binding
	Biological Process	Viral Process Positive Regulation Of CREB Transcription Factor Activity Macrophage Activation Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Energy Homeostasis	DNA Catabolic Process, Exonucleolytic RNA Catabolic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Viral Genome Replication Defense Response To Virus
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock
Drugs
Diseases
GWAS		Chromium levels ( 26025379) Colorectal cancer ( 29228715) Daytime sleep phenotypes ( 27126917) Gastroesophageal reflux disease ( 27485664) Heel bone mineral density ( 28869591) Inflammatory bowel disease ( 28067908 23128233) Information processing speed ( 21130836) Male-pattern baldness ( 28196072) Offspring birth weight ( 31043758) Response to exercise (triglyceride level interaction) ( 26491034) Ulcerative colitis ( 28067908)	Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)
Interacting Genes		11 interacting genes: AEN C15orf32 HAPLN3 KLHL12 RCCD1 RGMA SIK2 TICRR UNC45A WDR93 YWHAG	34 interacting genes: CRTC3 EMD EXOSC8 GNPTAB HOMEZ IKZF1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF473
Entrez ID		64784	64782
HPRD ID		13384	08573
Ensembl ID		ENSG00000140577	ENSG00000181026
Uniprot IDs		Q6UUV7 Q8TEF4	Q8WTP8
PDB IDs
Enriched GO Terms of Interacting Partners?
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