SH3BP2 and NSD2

		SH3BP2	NSD2
Description		SH3 domain binding protein 2	nuclear receptor binding SET domain protein 2
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GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Signal Transduction Positive Regulation Of Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		Cherubism	Multiple myeloma
GWAS		Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		24 interacting genes: ABL1 ARHGAP10 DBNL ERBB2 FGFR1 FLT3 FYN GRB2 LAT LCK NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	15 interacting genes: AGO2 APP AR AURKA ESR1 H3-4 H3C1 H3C14 MDC1 NELFA NOP14 PCNA SH3BP2 SLBP SMURF1
Entrez ID		6452	7468
HPRD ID		03657	04259
Ensembl ID		ENSG00000087266	ENSG00000109685
Uniprot IDs		A0A384N6E5 P78314	O96028
PDB IDs		2CR4 3TWR	5LSU 5VC8 6UE6
Enriched GO Terms of Interacting Partners?
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