SH3BP2 and PDLIM7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SH3BP2	PDLIM7
Description		SH3 domain binding protein 2	PDZ and LIM domain 7
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GO Annotations	Cellular Component		Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Phosphotyrosine Residue Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Signal Transduction Positive Regulation Of Signal Transduction	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development
Pathways			RET signaling
Drugs
Diseases		Cherubism
GWAS		Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		24 interacting genes: ABL1 ARHGAP10 DBNL ERBB2 FGFR1 FLT3 FYN GRB2 LAT LCK NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70	34 interacting genes: AP5B1 BSG CCDC185 DGCR6 ENKD1 FNDC11 GEM GFAP HNRNPD IQGAP1 MDM2 PAK5 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		6452	9260
HPRD ID		03657	10436
Ensembl ID		ENSG00000087266	ENSG00000196923
Uniprot IDs		A0A384N6E5 P78314	Q9NR12
PDB IDs		2CR4 3TWR	2Q3G
Enriched GO Terms of Interacting Partners?
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