BHMT and ALG9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		BHMT	ALG9
Description		betaine--homocysteine S-methyltransferase	ALG9 alpha-1,2-mannosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity	Alpha-1,2-mannosyltransferase Activity Mannosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage	Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation
Pathways		Sulfur amino acid metabolism Choline catabolism	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l)
Drugs		L-Methionine S-(D-Carboxybutyl)-L-Homocysteine Citric Acid
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)	Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5	3 interacting genes: BHMT H2AX VPS11
Entrez ID		635	79796
HPRD ID		04200	09504
Ensembl ID		ENSG00000145692	ENSG00000086848
Uniprot IDs		Q93088 V9HWA4	Q9H6U8
PDB IDs		1LT7 1LT8 4M3P
Enriched GO Terms of Interacting Partners?
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