ALG9 and VPS11

		ALG9	VPS11
Description		ALG9 alpha-1,2-mannosyltransferase	VPS11 core subunit of CORVET and HOPS complexes
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Late Endosome Membrane
	Molecular Function	Alpha-1,2-mannosyltransferase Activity Mannosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity	Nucleotide Binding Protein Binding Protein Domain Specific Binding Syntaxin Binding Protein Binding, Bridging Metal Ion Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Regulation Of Protein Stability Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Organelle Assembly Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l)
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Asthma or allergic disease (pleiotropy) ( 29785011)	Body mass index ( 29273807) Coronary artery disease ( 29212778)
Interacting Genes		3 interacting genes: BHMT H2AX VPS11	37 interacting genes: ALG9 BCAR1 BMI1 ECPAS EZR FUT1 GGA3 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MALL MARK3 MON1B MSN RAB7A RDX RILP RNF181 RNF26 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45 WNT1
Entrez ID		79796	55823
HPRD ID		09504	12258
Ensembl ID		ENSG00000086848	ENSG00000160695
Uniprot IDs		Q9H6U8	A0A087WXL6 B7Z879 Q9H270
PDB IDs
Enriched GO Terms of Interacting Partners?
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