BHMT and BBS2

Number of citations of the paper that reports this interaction (PubMedID 18000879)
7

Data Source:
BioGRID (two hybrid)

		BHMT	BBS2
Description		betaine--homocysteine S-methyltransferase	Bardet-Biedl syndrome 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cell Cytosol Microvillus Membrane Motile Cilium Stereocilium BBSome Ciliary Basal Body Neuron Projection Ciliary Membrane
	Molecular Function	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage	Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Sulfur amino acid metabolism Choline catabolism	BBSome-mediated cargo-targeting to cilium
Drugs		L-Methionine S-(D-Carboxybutyl)-L-Homocysteine Citric Acid
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)
Interacting Genes		6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5	11 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 HSCB KRT18 MDFI PAX2 PSME3 RBPMS
Entrez ID		635	583
HPRD ID		04200	05855
Ensembl ID		ENSG00000145692	ENSG00000125124
Uniprot IDs		Q93088 V9HWA4	Q9BXC9
PDB IDs		1LT7 1LT8 4M3P
Enriched GO Terms of Interacting Partners?
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