BDKRB2 and GRK6

Number of citations of the paper that reports this interaction (PubMedID 11517230)
15

Data Source:
HPRD (in vivo, in vitro)

		BDKRB2	GRK6
Description		bradykinin receptor B2	G protein-coupled receptor kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Membrane
	Molecular Function	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	G alpha (s) signalling events
Drugs		Anatibant Icatibant
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: ACE AGTR1 GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11	19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R
Entrez ID		624	2870
HPRD ID		00213	02925
Ensembl ID		ENSG00000168398	ENSG00000198055
Uniprot IDs		P30411	B3KPS5 P43250
PDB IDs			2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?
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