GRK6 and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 11504827)
8

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo, in vitro)

		GRK6	TBXA2R
Description		G protein-coupled receptor kinase 6	thromboxane A2 receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Acrosomal Vesicle Cell Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		G alpha (s) signalling events	Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs			Ridogrel Seratrodast
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	22 interacting genes: GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 NME2 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L YWHAZ
Entrez ID		2870	6915
HPRD ID		02925	01768
Ensembl ID		ENSG00000198055	ENSG00000006638
Uniprot IDs		B3KPS5 P43250	P21731 Q05C92 Q0VAB0
PDB IDs		2ACX 3NYN 3NYO	1LBN
Enriched GO Terms of Interacting Partners?
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