BDKRB2 and ACE

Number of citations of the paper that reports this interaction (PubMedID 17077303)
13

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo)

		BDKRB2	ACE
Description		bradykinin receptor B2	angiotensin I converting enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity	Endopeptidase Activity Carboxypeptidase Activity Drug Binding Metallopeptidase Activity Exopeptidase Activity Dipeptidyl-peptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Mitogen-activated Protein Kinase Binding Metallodipeptidase Activity
	Biological Process	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Regulation Of Renal Output By Angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Systemic Arterial Blood Pressure Proteolysis Spermatogenesis Regulation Of Blood Pressure Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Mononuclear Cell Proliferation Hormone Catabolic Process Peptide Catabolic Process Positive Regulation Of Blood Pressure Amyloid-beta Metabolic Process Arachidonic Acid Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Cell Proliferation In Bone Marrow Regulation Of Blood Vessel Diameter Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Metabolism of Angiotensinogen to Angiotensins
Drugs		Anatibant Icatibant	Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril
Diseases			Renal tubular dysgenesis Allograft rejection
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)	Adventurousness ( 30643258) Alzheimer's disease (late onset) ( 24162737 30820047) Angiotensin-converting enzyme activity ( 20066004) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 30072576) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 28135244 27841878 28739976) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 21886157) Metabolite levels ( 23281178) Serum metabolite levels ( 24625756 23093944) Systolic blood pressure ( 27841878 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 2 diabetes ( 30297969)
Interacting Genes		12 interacting genes: ACE AGTR1 GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11	5 interacting genes: AGTR2 BDKRB2 COMT CSNK2A1 DCAF7
Entrez ID		624	1636
HPRD ID		00213	00108
Ensembl ID		ENSG00000168398	ENSG00000159640
Uniprot IDs		P30411	B4DKH4 P12821
PDB IDs			1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P 4C2Q 4C2R 4CA5 4CA6 4UFA 4UFB 5AM8 5AM9 5AMA 5AMB 5AMC 6EN5 6EN6 6F9R 6F9T 6F9U 6F9V 6H5W 6H5X 6QS1
Enriched GO Terms of Interacting Partners?
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