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RELA and TP53BP2
Number of citations of the paper that reports this interaction (PubMedID
10498867
)
28
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
RELA
TP53BP2
Description
RELA proto-oncogene, NF-kB subunit
tumor protein p53 binding protein 2
Image
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytoplasm
Cytosol
I-kappaB/NF-kappaB Complex
NF-kappaB P50/p65 Complex
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Kinase Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Peptide Binding
Phosphate Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
Histone Deacetylase Binding
Transcription Regulatory Region DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
Ankyrin Repeat Binding
P53 Binding
SH3/SH2 Adaptor Activity
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Hair Follicle Development
Stimulatory C-type Lectin Receptor Signaling Pathway
Acetaldehyde Metabolic Process
Chromatin Organization
Regulation Of Transcription, DNA-templated
Inflammatory Response
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Aging
Positive Regulation Of Cell Proliferation
Animal Organ Morphogenesis
Response To Organic Substance
Response To UV-B
Positive Regulation Of Schwann Cell Differentiation
Viral Process
Cytokine-mediated Signaling Pathway
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Chondrocyte Differentiation
Positive Regulation Of Type I Interferon Production
Response To Muramyl Dipeptide
Response To Progesterone
Response To Insulin
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Protein Sumoylation
Cellular Response To Stress
Response To Cobalamin
Response To Cytokine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Response To Muscle Stretch
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Response To Morphine
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Interleukin-12 Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interleukin-8 Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Inflammatory Response
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To CAMP
Defense Response To Virus
Pri-miRNA Transcription By RNA Polymerase II
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Postsynapse To Nucleus Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Cellular Response To Angiotensin
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of MiRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Cell Cycle
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Drugs
Dimethyl fumarate
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Inflammatory bowel disease (
23128233
)
Sensation seeking (
30718321
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Urate levels (
31578528
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
195 interacting genes:
AATF
ACTL6A
AGO1
AHR
AKAP8
APBA2
AR
ARNT
AURKA
BATF2
BRCA1
BRMS1
BTK
BTRC
C1QB
CALM1
CAMK4
CARM1
CCL5
CCND2
CDC34
CDK9
CEBPB
CEBPD
CHEK1
CHUK
CNNM3
COL2A1
COMMD1
CREBBP
CSNK1G1
CSNK2A1
CSNK2A2
DDC
DDX1
DHX9
DNAJA3
DNMT3L
ECSIT
EEF1D
EGR1
EP300
EPHA2
ESR1
ETHE1
EZH2
FAF1
FKBP11
FOS
FUS
GLIS1
GOPC
GTF2B
HDAC1
HDAC2
HDAC3
HEXIM1
HMGA2
HMGB1
HSPA4
IGF1R
IKBKB
IKBKE
IKBKG
ING4
IRAK1BP1
IRF1
IRF2
IRF3
IRF8
IRF9
ISL1
JUN
KAT2A
KAT2B
KAT5
KDM2A
KEAP1
KPNA2
LATS2
LMO2
MAP2K6
MAP3K7
MAP3K8
MAPK10
MAPK14
MED15
MED23
MED7
MEN1
MKRN2
MST1R
MTPN
MX1
MYC
NCOA3
NCOA6
NCOR2
NFIC
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NKRF
NKX2-1
NOTCH1
NPM1
NR3C1
PARP1
PDCD11
PGR
PIAS1
PIAS3
PIK3CA
PIN1
PKM
PLA2G4A
PLK1
PML
POU2F1
PPARA
PPARG
PPP1R13L
PPP2CA
PPP2CB
PPP2R1B
PPP4C
PRKACA
PRKCZ
PRMT1
PRTN3
PSMD10
RAD51
RASSF1
REL
RELB
REPS2
RFC1
RIOK2
RNASE1
RNF25
RPL13
RPL23
RPS3
RPS6KA5
RXRA
SAT1
SETD7
SIN3A
SIRT1
SMAD3
SMAD4
SNIP1
SNRNP70
SOCS1
SOCS6
SORD
SP1
SRF
STAT1
STAT3
STAT6
TAF1
TAF11
TAF4B
TAF6
TAF9
TBK1
TBP
TCAP
TCF4
TERT
TGM2
TLE5
TNIP2
TP53
TP53BP1
TP53BP2
TRIB3
TRIP4
TSC22D3
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBE2L3
UNC5CL
USF2
USP7
ZBTB7A
ZBTB7B
64 interacting genes:
APP
ATPAF2
ATXN7
AXIN1
BAIAP2
BCL2
BCL2L1
CCDC92
CRK
CSNK2B
CWF19L2
DCUN1D1
EEF1A1
GRB2
H2BC4
HIF1AN
HNRNPUL1
HYOU1
KIF5A
LHX4
LMO4
MAGI1
MAPK8IP2
MRPL20
MTMR14
NAE1
NDC80
NFKB1
NUTM1
OTUB2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CC
PRKAB2
PRPF31
PTN
RELA
RXRB
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TXLNA
UBASH3A
UBE3A
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YWHAG
YWHAQ
ZGPAT
ZNF26
Entrez ID
5970
7159
HPRD ID
01241
11803
Ensembl ID
ENSG00000173039
ENSG00000143514
Uniprot IDs
A0A087X0W8
Q04206
Q13625
PDB IDs
1NFI
2LSP
2O61
3GUT
3QXY
3RC0
4KV1
4KV4
5U4K
5URN
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
Enriched GO Terms of Interacting Partners
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