TP53BP2 and MAGI1

Number of citations of the paper that reports this interaction (PubMedID 9169421)
41

Data Source:
HPRD (in vitro)

		TP53BP2	MAGI1
Description		tumor protein p53 binding protein 2	membrane associated guanylate kinase, WW and PDZ domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Junction Cell Projection Cell Periphery
	Molecular Function	P53 Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding	Protein Binding ATP Binding Protein C-terminus Binding Alpha-actinin Binding Molecular Adaptor Activity
	Biological Process	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator	Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Protein-containing Complex Assembly
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Triptolide cytotoxicity ( 26121980)	Adolescent idiopathic scoliosis ( 28334814) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Cobalt levels ( 26025379) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Crohn's disease-related phenotypes ( 25557950) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Knee osteoarthritis ( 28916551) Neurociticism ( 29500382) Neuroticism ( 25993607) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 23534349) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		64 interacting genes: APP ATPAF2 ATXN7 AXIN1 BAIAP2 BCL2 BCL2L1 CCDC92 CRK CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 H2BC4 HIF1AN HNRNPUL1 HYOU1 KIF5A LHX4 LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NFKB1 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CC PRKAB2 PRPF31 PTN RELA RXRB SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UBE3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26	24 interacting genes: ACTN4 ADGRB1 AMOT ASIC3 ATN1 CLCN5 CRHR1 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2
Entrez ID		7159	9223
HPRD ID		11803	04020
Ensembl ID		ENSG00000143514	ENSG00000151276
Uniprot IDs		Q13625	Q96QZ7
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP	1WBP 2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU 5N7D 5N7F 5N7G
Enriched GO Terms of Interacting Partners?
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