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RELA and EP300
Number of citations of the paper that reports this interaction (PubMedID
12456660
)
269
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, two hybrid, in vitro)
RELA
EP300
Description
RELA proto-oncogene, NF-kB subunit
E1A binding protein p300
Image
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytoplasm
Cytosol
I-kappaB/NF-kappaB Complex
NF-kappaB P50/p65 Complex
Glutamatergic Synapse
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Transcription Factor Complex
Chromosome
Cytosol
Protein-DNA Complex
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Kinase Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Peptide Binding
Phosphate Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
Histone Deacetylase Binding
Transcription Regulatory Region DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
NF-kappaB Binding
Repressing Transcription Factor Binding
Ankyrin Repeat Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Zinc Ion Binding
Acetyltransferase Activity
Transferase Activity, Transferring Acyl Groups
Chromatin DNA Binding
Activating Transcription Factor Binding
Nuclear Hormone Receptor Binding
Tau Protein Binding
Androgen Receptor Binding
NF-kappaB Binding
Peptide-lysine-N-acetyltransferase Activity
Protein Propionyltransferase Activity
Pre-mRNA Intronic Binding
STAT Family Protein Binding
Peptide Butyryltransferase Activity
Histone Crotonyltransferase Activity
Histone Butyryltransferase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Hair Follicle Development
Stimulatory C-type Lectin Receptor Signaling Pathway
Acetaldehyde Metabolic Process
Chromatin Organization
Regulation Of Transcription, DNA-templated
Inflammatory Response
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Aging
Positive Regulation Of Cell Proliferation
Animal Organ Morphogenesis
Response To Organic Substance
Response To UV-B
Positive Regulation Of Schwann Cell Differentiation
Viral Process
Cytokine-mediated Signaling Pathway
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Chondrocyte Differentiation
Positive Regulation Of Type I Interferon Production
Response To Muramyl Dipeptide
Response To Progesterone
Response To Insulin
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Protein Sumoylation
Cellular Response To Stress
Response To Cobalamin
Response To Cytokine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Response To Muscle Stretch
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Response To Morphine
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Interleukin-12 Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interleukin-8 Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Inflammatory Response
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To CAMP
Defense Response To Virus
Pri-miRNA Transcription By RNA Polymerase II
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Postsynapse To Nucleus Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Cellular Response To Angiotensin
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of MiRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Somitogenesis
Thigmotaxis
Behavioral Defense Response
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Glycolytic Process
Transcription-coupled Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Protein Acetylation
Internal Protein Amino Acid Acetylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Learning Or Memory
Circadian Rhythm
Animal Organ Morphogenesis
Regulation Of Autophagy
Macrophage Derived Foam Cell Differentiation
Regulation Of Mitochondrion Organization
Positive Regulation Of Neuron Projection Development
Viral Process
Histone Acetylation
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
B Cell Differentiation
Platelet Formation
Lung Development
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Complex Assembly
Protein Destabilization
Positive Regulation Of Protein Binding
Positive Regulation Of Type I Interferon Production
Cellular Response To UV
Multicellular Organism Growth
Megakaryocyte Development
Swimming
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Response To Estrogen
Positive Regulation By Host Of Viral Transcription
Histone H4 Acetylation
Histone H2B Acetylation
Fat Cell Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Face Morphogenesis
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Peptidyl-lysine Propionylation
Regulation Of Tubulin Deacetylation
Peptidyl-lysine Crotonylation
Peptidyl-lysine Butyrylation
Regulation Of Cellular Response To Heat
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection
Regulation of gene expression by Hypoxia-inducible Factor
RORA activates gene expression
RORA activates gene expression
Polo-like kinase mediated events
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Circadian Clock
Circadian Clock
B-WICH complex positively regulates rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
Metalloprotease DUBs
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NGF-stimulated transcription
NGF-stimulated transcription
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Drugs
Dimethyl fumarate
Diseases
Rubinstein-Taybi syndrome
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Inflammatory bowel disease (
23128233
)
Sensation seeking (
30718321
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Urate levels (
31578528
)
Autism spectrum disorder or schizophrenia (
28540026
)
Crohn's disease (
22936669
)
General risk tolerance (MTAG) (
30643258
)
Neuroticism (
29255261
)
Schizophrenia (
28991256
25056061
29483656
)
Type 2 diabetes (
30297969
)
Interacting Genes
195 interacting genes:
AATF
ACTL6A
AGO1
AHR
AKAP8
APBA2
AR
ARNT
AURKA
BATF2
BRCA1
BRMS1
BTK
BTRC
C1QB
CALM1
CAMK4
CARM1
CCL5
CCND2
CDC34
CDK9
CEBPB
CEBPD
CHEK1
CHUK
CNNM3
COL2A1
COMMD1
CREBBP
CSNK1G1
CSNK2A1
CSNK2A2
DDC
DDX1
DHX9
DNAJA3
DNMT3L
ECSIT
EEF1D
EGR1
EP300
EPHA2
ESR1
ETHE1
EZH2
FAF1
FKBP11
FOS
FUS
GLIS1
GOPC
GTF2B
HDAC1
HDAC2
HDAC3
HEXIM1
HMGA2
HMGB1
HSPA4
IGF1R
IKBKB
IKBKE
IKBKG
ING4
IRAK1BP1
IRF1
IRF2
IRF3
IRF8
IRF9
ISL1
JUN
KAT2A
KAT2B
KAT5
KDM2A
KEAP1
KPNA2
LATS2
LMO2
MAP2K6
MAP3K7
MAP3K8
MAPK10
MAPK14
MED15
MED23
MED7
MEN1
MKRN2
MST1R
MTPN
MX1
MYC
NCOA3
NCOA6
NCOR2
NFIC
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NKRF
NKX2-1
NOTCH1
NPM1
NR3C1
PARP1
PDCD11
PGR
PIAS1
PIAS3
PIK3CA
PIN1
PKM
PLA2G4A
PLK1
PML
POU2F1
PPARA
PPARG
PPP1R13L
PPP2CA
PPP2CB
PPP2R1B
PPP4C
PRKACA
PRKCZ
PRMT1
PRTN3
PSMD10
RAD51
RASSF1
REL
RELB
REPS2
RFC1
RIOK2
RNASE1
RNF25
RPL13
RPL23
RPS3
RPS6KA5
RXRA
SAT1
SETD7
SIN3A
SIRT1
SMAD3
SMAD4
SNIP1
SNRNP70
SOCS1
SOCS6
SORD
SP1
SRF
STAT1
STAT3
STAT6
TAF1
TAF11
TAF4B
TAF6
TAF9
TBK1
TBP
TCAP
TCF4
TERT
TGM2
TLE5
TNIP2
TP53
TP53BP1
TP53BP2
TRIB3
TRIP4
TSC22D3
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBE2L3
UNC5CL
USF2
USP7
ZBTB7A
ZBTB7B
372 interacting genes:
ABL1
ACSM5
ACTA2
ACTB
AHR
AKT1
ALKBH4
ALX1
APEX1
AR
ARHGDIA
ARNT
ARNTL
ARSF
ASCL1
ASH2L
ATF4
ATF5
ATR
AUTS2
BAG6
BCAS2
BCL3
BCL6
BRCA1
BRMS1
C1R
CALCOCO1
CARM1
CCNB1
CCND1
CDK1
CDK2
CDT1
CDX2
CEBPA
CEBPB
CEBPD
CFH
CHD4
CITED1
CITED2
CITED4
CLOCK
CNOT4
COPS2
COPS6
CREBBP
CRX
CTBP1
CTBP2
CTF1
CTNNB1
CXCL8
CXXC1
DAO
DBP
DDIT3
DDX24
DDX5
DECR2
DEK
DTX1
DUX4
E2F1
E2F5
EEF1A1
EEF2
EGR1
EID1
EID2
ELF3
ELK1
EMB
EPAS1
EPO
ESR1
ESR2
ETS1
ETS2
ETV1
ETV4
FBXL5
FEN1
FHL2
FOSB
FOSL1
FOSL2
FOXO3
FOXP3
GAA
GABPA
GATA2
GATA4
GATA5
GATA6
GCKR
GLUL
GOLGA2
GPBP1
GPS2
GRB2
GRIP1
GTF2B
H1-1
H1-3
H2AC20
H2AC21
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C14
H4C9
HAND2
HBP1
HDAC1
HDAC3
HDAC6
HEMGN
HERC1
HIF1A
HIPK2
HMGB1
HMGN1
HMGN2
HNF1A
HNRNPU
HNRNPUL1
HOXA10
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD4
HPS6
HSP90AA2P
ILF2
ILF3
IMMT
ING1
ING2
ING4
ING5
IRF1
IRF2
IRF3
IRF5
IRF7
ITIH3
JDP2
JMY
JUN
JUNB
JUND
KAT2A
KAT2B
KAT5
KCTD5
KLF1
KLF13
KLF2
KLF4
KLF5
KPNA2
KRT18
LEF1
MAF
MAGED1
MAML1
MAP2K1
MAP3K5
MAPK1
MAPK8
MAPT
MAX
MCL1
MCM2
MCM3
MCM3AP
MCM4
MCM5
MDC1
MDM2
MDM4
MEF2A
MEF2C
MEF2D
MGMT
MITF
MN1
MORF4L1
MPG
MRE11
MSH6
MSTO1
MTOR
MYB
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NAP1L4
NBN
NCOA1
NCOA2
NCOA3
NCOA6
NEDD1
NEIL2
NEUROD1
NFATC1
NFATC2
NFYB
NOTCH1
NOXA1
NPAS2
NPM1
NR1H4
NR1I2
NR2F2
NR4A1
NUP98
NUPR1
OLIG2
ORC2
PAK2
PAX5
PAX6
PAX8
PAXIP1
PCK2
PCNA
PDHX
PELP1
PIAS1
PIAS3
PIN1
PLAGL1
PLG
PLSCR1
PLSCR2
PML
POLB
POLD2
POLI
POU3F2
PPARA
PPARD
PPP2R5C
PRKCA
PRKCB
PRKCD
PRKDC
PRMT1
PROX1
PTMA
RACK1
RAD23A
RAD50
RAN
RB1
RBM14
RBX1
RECQL4
REL
RELA
RORA
RPL27
RPS6KA5
RPS6KB1
RPS6KB2
RUNX1
RUNX2
RUNX3
RUVBL2
SATB1
SAV1
SELENOP
SENP3
SERTAD1
SET
SETD1A
SIRT1
SIRT2
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD7
SNAI1
SNIP1
SNW1
SOX9
SP1
SP3
SPHK1
SPIB
SREBF1
SREBF2
SRY
SS18
SS18L1
STAT1
STAT2
STAT3
STAT5A
STAT5B
STAT6
SUB1
SUMO2
SUV39H1
TACC2
TADA3
TAF1B
TAL1
TCF12
TCF3
TCF4
TCF7L2
TDG
TERF2
TFAP2A
TGFB1I1
TGS1
THPO
TINAGL1
TNIP2
TP53
TP53BP1
TP63
TP73
TRAF2
TRERF1
TRIP4
TSG101
TWIST1
UBC
UBE2D1
UBE2I
UBQLN1
UBTF
USF2
VPS18
WDR59
WDR82
XRCC6
YWHAZ
YY1
ZBTB16
ZBTB17
ZBTB48
ZBTB49
ZBTB7B
ZBTB8A
ZC3H12A
ZEB1
ZFPM2
ZNF148
ZNF76
ZRANB2
Entrez ID
5970
2033
HPRD ID
01241
04078
Ensembl ID
ENSG00000173039
ENSG00000100393
Uniprot IDs
A0A087X0W8
Q04206
Q09472
Q7Z6C1
PDB IDs
1NFI
2LSP
2O61
3GUT
3QXY
3RC0
4KV1
4KV4
5U4K
5URN
1L3E
1P4Q
2K8F
2MH0
2MZD
3BIY
3I3J
3IO2
3P57
3T92
4BHW
4PZR
4PZS
4PZT
5BT3
5KJ2
5LKT
5LKU
5LKX
5LKZ
5LPK
5LPM
5NU5
5XZC
6DS6
6FGN
6FGS
6GYR
6GYT
6K4N
6PF1
6PGU
Enriched GO Terms of Interacting Partners
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